In some cases, this inflammation of the pancreas may be related to gallstones. In others, it may be a side effect of immunomodulators or mesalamine used to treat IBD, requiring discontinuation of the drug in question. Even after the pancreatitis is resolved, the drug should not be reinstituted. If gallstones are the cause, a stone may have passed down the common bile duct to the area where it joins the pancreas. Symptoms include severe abdominal pain, nausea, vomiting, and fever. Surgical removal of the stone resolves the inflammation.