Radiculopathy occurs when something irritates a spinal nerve—say a “slipped disc” causing a pinched nerve. This is also called sciatica . There are resident stem and other cells in the local tissues everywhere in our body. Many live around blood vessels. These are obviously also present in the disc and nerves in the epidural space and they usually play an important role in suppressing inflammation and repairing damage. We know, based on a copious in vitro (lab) data, that the high-dose steroids used in epidural injections can kill these cells. So the progression of the series of epidural steroid injections looks a little something like this:
Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]
Steroid and antibiotic eye drops - hydrocortisone/neomycin/polymixin B; loteprednol/tobramycin; prednisolone/gentamycin; prednisolone/sulfacetamide; hydrocortisone /neomycin/bacitracin/ polymyxin B (Blephamide, Catapred [discontinued], Isopto, Pred-G, Poly-Pred [discontinued], Tobradex, Zylet and many other brands) are steroid and antibiotic eye drops prescribed to prevent or treat eye infections that are associated with inflammation. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to using these medications.