Organon was founded by Dr. Saal van Zwanenberg in Oss , the Netherlands , in 1923 as Zwanenberg-Organon. Its first product was insulin in 1923.  In the thirties it manufactured estrogens .  In 1948, Organon acquired the Newhouse research site in Scotland , United Kingdom . The production of cortisone was initiated in 1953.  In 1962 it bought the stock of the Nederlandsche Cocaïnefabriek . The now named Koninklijke Zwanenberg-Organon ( KZO ) fused with the fibre producer AKU in 1969 to become AKZO, later Akzo Nobel. Organon was the human health care business unit of Akzo Nobel and transferred its headquarters to New Jersey , USA  while the main headquarters of Akzo Nobel remained in Arnhem , and has since moved to Amsterdam . Manufacturing facilities are in the Netherlands, Germany, the United Kingdom, Ireland, China, Japan, and the USA.