The first edition of the FCC, which was published in 1966 by the Institute of Medicine, was given quasi-legal recognition in July 1966 by means of a letter of endorsement from FDA Commissioner James L. Goddard, which was reprinted in the book. The letter stated that "the FDA will regard the specifications in the Food Chemicals Codex as defining an 'appropriate food grade' within the meaning of Sec. (b)(3) and Sec. (a)(2) of the food additive regulations, subject to the following qualification: this endorsement is not construed to exempt any food chemical appearing in the Food Chemicals Codex from compliance with requirements of Acts of Congress or with regulations and rulings issued by the Food and Drug Administration under authority of such Acts."
T3 and T2 were compared to one another mano-a-mano in a clinical study comparing their effect on resting metabolism and oxidative capacity of metabolically active tissues (effects on muscle tissue, fat, brown adipose tissue, liver, and heart). T2 had a blatant dose-dependent effect which increased resting metabolism and oxidative capacity, exponentially increasing how much fat you can lose. Another study showed very promising and similar results, increased energy expenditure and oxidative capacity as a result of T2. It soon became evident that T2 has a very similar effect on lipid metabolism that T3 itself has.
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