Bed bugs were once a common public health pest worldwide, but declined in incidence through the mid 20th century. However, bed bugs have undergone a dramatic, worldwide resurgence since they have now evolved resistance to common insecticides. Bed bugs are one of the great travelers of the world and are readily transported via luggage, clothing, bedding, and furniture. To get rid of bed bugs, act at the first signs of infestation and use an integrated pest management approach involving prevention, sanitation, and chemical treatment. Bed bugs can be persistent, so you'll need to demonstrate a greater level of persistence if you want to eliminate them.